BCVR
第2回日本循環器学会基礎研究フォーラム
The 2nd JCS Council Forum on Basic CardioVascular Research

プログラム

日程表

Program at a Glance(PDF) Poster Presentation(PDF)

Keynote Lecture

Keynote Lecture 1

9月22日(土) 17:00-17:50 第1会場(能楽ホール)

Targeting GRK2 in the Failing Heart

Walter J. Koch
(Former Chair, Council on Basic Cardiovascular Sciences(BCVS); Lewis Katz School of Medicine, Temple University School of Medicine, USA)

Chairperson: Yoshihiko Saito (Department of Cardiovascular Medicine, Nara Medical University)

Keynote Lecture 2

9月23日(日) 13:10-14:00 第1会場(能楽ホール)

3D Heart muscles from induced pluripotent stem cells for drug screening, disease modelling and cardiac repair

Thomas Eschenhagen
(President of International Society for Heart Research (ISHR) European Section; Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Germany)

Chairperson: Issei Komuro (Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo)

共催:武田薬品工業株式会社


Sponsored Symposium

Sponsored Symposium 1

Heart Failure

9月22日(土) 11:00~12:30 第1会場(能楽ホール)

座長: 矢野 雅文(山口大学医学部医学科 器官病態内科学)
桑原 宏一郎(信州大学医学部 循環器内科学)

共催:大塚製薬株式会社

講演者:

SS1-1PP2A/HSP70 dynamically regulates HDAC2 S394 phosphorylation and its activity in cardiac hypertrophy
Hyun Kook (Chonnam National University Medical School, South Korea)
SS1-2Effects of sodium/glucose cotransporter 1 inhibitor on hypertrophic cardiomyopathy.
弘瀬 雅教(岩手医科大学薬学部)
SS1-3Epigenomic regulation of cardiac remodeling during heart failure
桑原 宏一郎(信州大学医学部 循環器内科学)
SS1-4Protective role of intercalated disk protein afadin in the pressure-overloaded heart
扇田 久和(滋賀医科大学 分子病態生化学)

Sponsored Symposium 2

発生・再生

9月22日(土) 11:00~12:30 第2会場(会議室1・2)

座長: 福田 恵一(慶応義塾大学 循環器内科)
Hyo-soo Kim(Department of Internal Medicine at Seoul National University College of Medicine, South Korea)

共催:アステラス製薬株式会社/アステラス・アムジェンバイオファーマ株式会社

講演者:

SS2-1New cell surface receptor that specifies cardiac lineage commitment during differentiation from iPSCs and heart development in mouse and human
Hyo-soo Kim(Department of Internal Medicine at Seoul National University College of Medicine, South Korea)
SS2-2Myocardial Tissue Engineering for Regenerative Therapy and Drug Screening
清水 達也(東京女子医科大学 先端生命医科学研究所)
SS2-3Safe and Effective Cardiac Regenerative Medicine with Human iPSCs
遠山 周吾(慶應義塾大学医学部 循環器内科)
SS2-4Generation of a Pacemaker Cells from Human Induced Pluripotent Stem Cells: Progress and Issues
青山 純也(日本医科大学付属病院 心臓血管外科)

Sponsored Symposium 3

代謝・ミトコンドリア

9月22日(土) 15:10~16:40 第1会場(能楽ホール)

座長: 三浦 哲嗣(札幌医科大学 循環器・腎臓・代謝内分泌内科学講座)
井手 友美(九州大学大学院医学研究院 循環器内科学)

共催:アストラゼネカ株式会社 / 小野薬品工業株式会社

講演者:

SS3-1Mitochondrial fusion and fission proteins as targets for cardioprotection
Derek J Hausenloy(Duke-National University Singapore, Singapore)
SS3-2Mass spectrometry-based omics approach reveals multifaceted roles of mitochondrial metabolism in the drug target, muscle differentiation, and maintaining its own DNA.
瀬戸山 大樹(九州大学病院 検査部)
SS3-3Essential components to induce PINK1-Parkin mediated mitophagy
星野 温(京都府立医科大学大学院医学研究科 循環器内科学)
SS3-4The critical roles of coagulation factors in inducing brown adipose tissue dysfunction in obesity.
林 由香(新潟大学大学院医歯学総合研究科 循環器内科学分野)

Sponsored Symposium 4

臓器ネットワーク

9月22日(土) 15:10~16:40 第2会場(会議室1・2)

座長: 佐藤 匠徳(株式会社国際電気通信基礎技術研究所 佐藤匠徳特別研究所)
眞鍋 一郎(千葉大学大学院医学研究院 長寿医学講座)

共催:MSD株式会社

講演者:

SS4-1Senescence, the endothelium and a vascular protective gene
Jennifer Gamble(Centenary Institute, The University of Sydney, Australia)
SS4-2Organ specific gene regulation by distinct vascular mechanisms during development.
佐藤 匠徳(国際電気通信基礎技術研究所)
SS4-3Immunometabolism in macrophage as a novel therapeutic target of metabolic syndrome
大石 由美子(日本医科大学大学院医学研究科 代謝・栄養学分野)
SS4-4Specific Neural Stimulations Modulate the Formation of Immune Cell Gateways into the CNS
上村 大輔(北海道大学遺伝子病制御研究所・大学院医学院 分子神経免疫学分野)

Sponsored Symposium 5

ゲノム・エピジェネティクス

9月23日(日) 9:00~10:30 第1会場(能楽ホール)

座長: 高島 成二(大阪大学大学院医学系研究科・生命機能研究科 医化学講座)
尾野 亘(京都大学大学院医学研究科 循環器内科)

講演者:

SS5-1Developing new Treatments for Cardiomyopathy
Jianming Jiang(National University of Singapore, Singapore)
SS5-2Genetic analysis of more than 100K Japanese subjects including cardiovascular disorders
鎌谷 洋一郎(京都大学大学院医学研究科 ゲノム医学センター)
SS5-3Practice and Application of Whole Exome Sequencing in Hereditary Heart Disease
朝野 仁裕(大阪大学大学院医学系研究科 循環器内科学)
SS5-4Single-nucleus RNA-seq analysis reveals pathogenic transcriptional programs in human heart failure.
藤田 寛奈(東京大学大学院医学系研究科内科学専攻循環器内科学)

Sponsored Symposium 6

血管

9月23日(日) 9:00~10:30 第2会場(会議室1・2)

座長: 室原 豊明(名古屋大学大学院医学系研究科 循環器内科)
久保田 義顕(慶応義塾大学医学部 解剖学教室)

共催:武田薬品工業株式会社

講演者:

SS6-1TIE receptor mediated signaling in lymphatic and blood vascular formation and maintenance
Yulong He(Cyrus Tang Medical Institute, Soochow University, China)
SS6-2Impact of vascular endothelial stem cells on vascular integrity
高倉 伸幸(大阪大学微生物病研究所 情報伝達分野)
SS6-3The biological functions of thrombomodulin in endothelial cells
Hua-Lin Wu(Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Taiwan)
SS6-4Role of thrombospondin-1 in mechanotransduction and development of thoracic aortic aneurysm
山城 義人(筑波大学)

Sponsored Symposium 7

肺高血圧・血管炎

9月23日(日) 14:00~15:30 第1会場(能楽ホール)

座長: 中岡 良和(国立循環器病研究センター研究所 血管生理学部)
江本 憲昭(神戸薬科大学 臨床薬学研究室)

講演者:

SS7-1VEGFR3 as a novel modulator of BMP signaling in pulmonary hypertension
Suk-Won Jin(Gwangju Institute of Science and Technology, South Korea/Yale University, USA)
SS7-2Inlerleukin-6 Blockade Therapy for Pulmonary Arterial Hypertension and Large Vessel Vasculitis
中岡 良和(国立循環器病研究センター研究所 血管生理学部)
SS7-3Cell-cell Contact Promotes Endothelial Integrity by BMPR2 Mediated Metabolic and Epigenetic Changes
宮川 一也(神戸薬科大学 臨床薬学研究室)
SS7-4The single nucleotide polymorphism of MLX gene is involved in the development of Takayasu Arteritis
前嶋 康浩(東京医科歯科大学医学部附属病院 循環器内科)

Sponsored Symposium 8

不整脈

9月23日(日) 14:00~15:30 第2会場(会議室1・2)

座長: 古川 哲史(東京医科歯科大学 難治疾患研究所 生体情報薬理分野)
小野 克重(大分大学医学部 病態生理学講座)

共催:バイエル薬品株式会社

講演者:

SS8-1Cardiovascularpathophysiology of fatty acid binding proteins
Wei Wang(Department of Physiology/Department of Biochemistry and Molecular Biology, Hebei Medical University, China)
SS8-2Redox Physiology of TRP channels
森 泰生(京都大学大学院工学研究科)
SS8-3Extracellular nucleotides: Novel players for the pathogenesis of atrial fibrillation
笹野 哲郎(東京医科歯科大学 循環生理解析学)
SS8-4Single Cell Analysis of CALM-related LQT iPS Cell model using membrane voltage imaging system
山本 雄大(京都大学医学部附属病院 循環器内科電気生理研究室)

基礎研究助成

日時:9月23日(日)10:30-11:45
会場:第1会場(能楽ホール)

座長:

望月 直樹(国立循環器病研究センター研究所)
福田 恵一(慶応義塾大学 循環器内科)

発表者:

GS-1Systematic comprehension of developmental origins of adult-onset cardiovascular diseases
有馬 勇一郎(熊本大学大学院生命研究部循環器内科)
GS-2New Insight into the Molecular Drug Target of Cardio-renal Syndrome
熊澤 拓也(奈良県立医科大学 循環器内科学)
GS-3Development of in vivo four-dimensional [4D] metabolism imaging
勝俣 良紀(慶應義塾大学 循環器内科)
GS-4Mitochondria-nucleus network for a novel therapy against heart failure
星野 温(京都府立医科大学 循環器内科)
GS-5Myocardial Regeneration by Engineering Mitochondrial Turnover
木村 航(理科学研究所・生命機能科学研究所センタ-)

Award Session

日時:9月22日(土) 13:55-15:10
会場:第1会場(能楽ホール)

座長:

南野 哲男(香川大学医学部 循環器・腎臓・脳卒中内科学)
家田 真樹(筑波大学医学医療系 循環器内科)

発表者:

AS-1Cell-free DNA Released in Atrial Fibrillation Promotes Systemic Pro-Inflammatory Cytokine Expression
Masahiro Yamazoe (Tokyo Medical and Dental University)
AS-2Increased Gαo expression underlies cardiac dysfunction accompanied with abnormal Ca2+ handling
Hideaki Inazumi (Kyoto University Graduate School of Medicine)
AS-3Direct Reprogramming with Sendai Virus Vectors Improves Cardiac Function In Vitro and In Vivo
Kazutaka Miyamoto (Keio University School of Medicine)
AS-4Blockade of NKG2D / NKG2D Ligand Interaction Attenuated Post-infarct Myocardial Injury
Kotaro Matsumoto (Osaka University)
AS-5(Pro)renin receptor promotes development of sarcopenia via activation of Wnt- YAP signaling pathway
Jin Endo (Keio University School of Medicine)

Luncheon Seminar

Luncheon Seminar 1

武田 憲彦(東京大学大学院医学系研究科 循環器内科)
湯浅 慎介(慶應義塾大学 循環器内科)

座長:吉村 道博(東京慈恵会医科大学 循環器内科)
共催:武田薬品工業株式会社

Luncheon Seminar 2

岸 拓弥(九州大学循環器病未来医療研究センター)

座長:坂田 泰史(大阪大学 循環器内科)
共催:田辺三菱製薬株式会社

Luncheon Seminar 3

赤澤 宏(東京大学大学院医学系研究科 循環器内科)

座長:筒井 裕之(九州大学大学院医学研究院 循環器内科)
共催:ブリストル・マイヤーズ スクイブ株式会社 / ファイザー株式会社

Luncheon Seminar 4

堀中 繁夫(獨協医科大学 循環器・腎臓内科)

座長:小室 一成(東京大学大学院医学系研究科 循環器内科学)
共催:第一三共株式会社

Luncheon Seminar 5

菅沼 正司(菅沼医院)

座長:三浦 哲嗣(札幌医科大学医学部 循環器・腎臓・代謝内分泌内科学講座)
共催:日本ベーリンガーインゲルハイム株式会社


Poster

ポスター発表を行う演題の中から、当日審査を行いPoster Awardを選出します。
受賞者には副賞を授与いたします。

日時:9月22日(土)18:00-19:00
会場:第4会場(2階 レセプションホール1)

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Poster session 1

Aging

座長:塩島 一朗(関西医科大学)
発表者:
P01-1 Nucleolus-mediated Cellular Senescence is involved in Heart Failure
Takuya Kumazawa (Cardiovascular Medicine, Nara Medical University, Japan)
P01-2 Amino acid substitution of Werner gene is responsible for cardiac aging
Takahiro Kamihara (Department of Cardiology, Nagoya University Graduate School of Medicine)
P01-3 Endothelial-SASP induces premature senescence in adipocytes and disrupts metabolic homeostasis
Agian Jeffilano Barinda (Clinical Pharmaceutical Laboratory, Kobe Pharmaceutical University)
P01-4 Endothelial cell senescence exacerbates heart failure due to pressure-overload
Dhite B Nugroho (Department of Internal Medicine, Division of Cardiovascular Medicine, Graduate school of medicine, Kobe University)
P01-5 Repetitive Postprandial Combined Metabolic Spikes Induce Premature Aging of Bone Marrow
KEITA HORITANI (Department of Medicine II Kansai Medical University)
P01-6 Visceral adipose tissue potentiates cardiac dysfunction in aging and obesity
Daigo Sawaki (INSERM U955, University of Paris East Créteil)
P01-7 Osteoprotegerin as a protective factor in the aging heart
Toshihiro Tsuruda (University of Miyazaki)
P01-8 Endothelial cell senescence is involved in the progression of atherosclerosis
Sakiko Honda (Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine)


Poster session 2

Aortopathy

座長:前嶋 康浩(東京医科歯科大学 循環器内科)
発表者:
P02-1 Molecular bases for the sex difference in aortic aneurysm formation in Marfan syndrome
Qing Liu (Graduate School of Medicine and Faculty of Medicine, The University of Tokyo)
P02-2 The integrity of extracellular matrix affects transduction of mechanical stress in the aortic wall
THANG QUOC BUI (Department of Cardiovascular Surgery, University of Tsukuba)
P02-3 Cell-specific function of fibulin-4 in progression of ascending aortic aneurysm in mice
Caroline Antunes Lino (Department of Anatomy, University of Sao Paulo, Institute of Biomedical Sciences, Sao Paulo, Brazil)
P02-4 Role of PAR1-Egr1 in the initiation of thoracic aortic aneurysm
Seungjae Shin (Tsukuba university)
P02-5 The role of Syk in pathogenesis of aortic dissection
Youhei Hashimoto (Department of Internal Medicine, Division of Cardiovascular Medicine, Kurume University School of Medicine)
P02-6 Involvement of Focal adhesion kinase in pathogenesis of aortic dissection
Ryohei Majima (Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine)
P02-7 Impact of CD44 on the development of thoracic aortic aneurysm and dissection in mice
Omer Hatipoglu (Okayama University)
P02-8 Angiotensin receptor-Neprilysin Inhibition Attenuates Aortic Aneurysm in Mice
Kouhei Tashiro (Fukuoka University School of Medicine)



Poster session 3

Atherosclerosis/Thromboembolism1

座長:的場 哲哉(九州大学大学院医学研究院 循環器内科学)
発表者:
P03-1 30-day morbidity and mortality of patients with acute coronary syndrome
Thatsaphone Somsaart (Setthathirath Hospital)
P03-2 STEMI PATIENT IN TYPE C HOSPITAL : TREAT OR NOT TO TREAT ?
Lianita Gumdani (Mekarsari Hospital)
P03-3 Aortic valve calcification and coronary atherosclerosis in familial hypercholesterolemia patients
Eri Yamamoto (Department of Cardiology, Tokyo Women's Medical University)
P03-4 Stabilization of symptomatic carotid atherosclerotic plaques by statins: A pathological analysis
Takao Konishi (Department of Cancer Pathology, Hokkaido University, Graduate School of Medicine)
P03-5 Validation of OCT findings in vivo plaque histology obtained by directional coronary atherectomy
Hiroshi Okamoto (Kawasaki medical school)
P03-6 Influence of thrombin on the structure of platelet glycoprotein Ibα binding to von Willebrand factor
Shinichi Goto (Keio University School of Medicine)
P03-7 Different impact of thrombin generation rate and enzymatic effects of thrombin on thrombus growth.
Shinichi Goto (Keio University School of Medicine)
P03-8 Bacteroides inhibits atherosclerosis by regulating gut microbial LPS production
Naofumi Yoshida (Kobe University Graduate School of Medicine)



Poster session 4

Atherosclerosis/Thromboembolism2

座長:大橋 浩二(名古屋大学大学院医学系研究科 分子循環器医学)
発表者:
P04-1 Comprehensive analysis of HIF-1a target genes in macrophage adaptation to the microenvironment
Takayuki Isagawa (Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences)
P04-2 Telomerase Deficiency Prevents Vascular Smooth Muscle Cell Proliferation and Neointima Formation
Jun Aono (Department of Cardiology, Pulmonology, Hypertension, and Nephrology, Ehime University Graduate School of Medicine)
P04-3 Glucocorticoid decreases uptake of Ac-LDL through suppression of JAK-STAT pathway in macrophages
Ryota Hashimoto (Department of Physiology, Juntendo University Faculty of Medicine)
P04-4 Direct interaction between adiponectin and oxidized LDL limits their action each other
Akemi Kakino (Department of Physiology, Shinshu University School of Medicine)
P04-5 DPP-4 inhibitors protect HUVECs from hypoxia-induced apoptosis and vascular barrier impairment
Masanori Hirose (Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine)
P04-6 Pericyte-specific deletion of Ninjurin1 induces abnormal vasa vasorum and intimal hyperplasia.
Kiwamu Horiuchi (Department of Cardiovascular Regeneration and Innovation, Asahikawa medical university)
P04-7 Metabolic Stress Evokes Mitochondrial Dysfunction and Vascular Senescence via Mitochondrial Fission
Yoshihiro Uchikado (Cardiovascular Medicine and Hypertension, Graduate School of Medicine, Kagoshima University)
P04-8 Angiotensin Receptor Neprilysin Inhibitor Preserved Cardiac Function in Atherosclerotic Mouse
Yasunori Suematsu (Fukuoka University)



Poster session 5

Cardiac Hypertrophy and Function1

座長:扇田 久和(滋賀医大 生化学・分子生物学講座)
発表者:
P05-1 Protein kinase N promotes cardiac hypertrophy and fibrosis
Teruhiro Sakaguchi (Nagoya university)
P05-2 Cavin-2/SDPR Deficiency Attenuates Myofibroblast Differentiation and Cardiac Fibrosis in TAC Mice
Yusuke Higuchi (Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine)
P05-3 Sirt7 plays a distinct role in cardiomyocyte and non-cardiomyocyte in response to pressure overload
Satoru Yamamura (Kumamoto Univercity)
P05-4 The Potent p300-HAT Inhibitor GO-Y030 Suppresses TAC-induced Development of Heart Failure in mice
Kana Shimizu (Division of Molecular Medicine, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka)
P05-5 Amlexanox or Dantrolene prevents angiotensin II-induced cardiac hypertrophy in neonatal myocytes
Tetsuro Oda (Department of Medicine and Clinical Science, Division of Cardiology,Yamaguchi University Graduate School of Medicine)
P05-6 A ryanodine receptor stabilizer as a novel strategy for pressure-overloaded heart failure
Michiaki Kohno (Yamaguchi University)
P05-7 Verification of novel molecular mechanism of cardiac hypertrophy via regulation of mRNA degradation
Yuki Masumura (Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine)
P05-8 A Novel Long Noncoding RNA Protects the Heart from Heart Failure Accompanied by Renal Dysfunction
Takuya Kumazawa (Cardiovascular Medicine, Nara Medical University, Japan)



Poster session 6

Cardiac Hypertrophy and Function2

座長:藤野 陽(金沢大学医薬保健研究域 保健学系)
発表者:
P06-1 Analysis of molecular dynamics of TN-C in Kawasaki disease using a murine model induced by FK565
Daiki Yamamoto (Departmtent of Pathology and Matrix Biology, Mie University Graduate School of Medicine)
P06-2 Cocoa Bean Polyphenols Inhibit Pressure Overload-Induced Cardiac Hypertrophy and Heart Failure
Nurmila Sari (Division of Molecular Medicine, Graduate School of Pharmaceutical Sciences, University of Shizuoka)
P06-3 Guanylyl Cyclase-A Signaling Attenuates the Deleterious Salt Effect on Mineralocorticoid Receptor
Hitoshi Nakagawa (Nara Medical University)
P06-4 α1A-adrenergic receptor suppresses cardiac hypertrophy in pregnancy-associated hypertensive mice
Chulwon Kwon (Graduate school of Life and Environmental Sciences, University of Tsukuba,Tsukuba, Ibaraki, Japan)
P06-5 Left Ventricular Global Longitudinal Strain Values in Healthy Filipino Adults: Cross sectional Study
Julius Caesar de Vera (St. Luke's Medical Center-Global City)
P06-6 Right Ventricular Strain in Healthy Adult Filipinos A Retrospective Cross Sectional Pilot Study
Julius Caesar de Vera (St. Luke's Medical Center-Global City)
P06-7 Change of exhaled acetone concentration levels in patients with acute decompensated heart failure
Tetsuro Yokokawa (Department of Cardiovascular Medicine, Fukushima Medical University)



Poster session 7

Development and Differentiation/Regeneration

座長:吉田 善紀(京都大学 iPS細胞研究所)
発表者:
P07-1 Transcriptional regulation and physiological significance of ALK1 target genes in endothelial cells
Osamu Nakagawa (Department of Molecular Physiology, National Cerebral and Cardiovascular Center Research Institute)
P07-2 Significance of Hey transcriptional factors in endothelial cells during cardiovascular development
Osamu Nakagawa (Department of Molecular Physiology, National Cerebral and Cardiovascular Center Research Institute)
P07-3 A novel origin of ECs; Isl1-positve cells contribute to caudal vessel formation in zebrafish

Hiroyuki Ishikawa ( National Cerebral and Cardiovascular Center Research Institute)

P07-4 Identification of new myocardial growth factor and its application to cardiac regeneration
Sho Haginiwa (Keio University)
P07-5 tie1 but not tie2 is essential for cardiovascular development in zebrafish
Nanami Morooka (National Cerebral and Cardiovascular Center)
P07-6 Myocardial canonical Wnt signaling in zebrafish heart development
Ayano Chiba (National Cerebral and Cardiovascular Center Research Institute)
P07-7 Extended in vitro culture enhanced maturation and engraftment of human iPSC-derived cardiomyocytes
Shin Kadota (Department of Regenerative Science and Medicine, Shinshu University)
P07-8 EFFICIENT CARDIAC REGENERATION THERAPY BY CELL CYCLE ACTIVATION OF IPSC-DERIVED CARDIOMYOCYTES
Mnabu Kasamoto (Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine)



Poster session 8

Drug Discovery/Translational Research

座長:中神 啓徳(大阪大学)
発表者:
P08-1 Development of PCSK9 epitope vaccine for dyslipidemia in mice
Hironori Nakagami (Osaka University)
P08-2 Algorithmic Auto-Recreation System of hiPSC-CMs Simulation and Prediction of Drug Testing
Hirohiko Kohjitani (Department of Cardiovascular Medicine, Kyoto University Hospital)
P08-3 Development of a new high-throughput screening assay for the discovery of novel heart failure drugs
Hikaru Moki (Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan)
P08-4 A bacteria-derived ACE2-like enzyme suppresses cardiac remodeling and dysfunction in mice.
Takafumi Minato (Akita University Graduate School of Medicine)
P08-5 The effect of mTORC1 inhibition on necroptotic signaling-mediated suppression of autophagic flux
Koki Abe (Sapporo Medical University, Department of Cardiovascular, Renal and Metabolic Medicine)
P08-6 Silencing of microRNA-34a ameliorates aortic valve calcification via Notch1-Runx2 signaling
Taku Toshima (Yamagata University School of Medicine)
P08-7 A Novel Target Molecule of Nobiletin possess a Therapeutic Potency for Heart Failure in Mice
Yoichi Sunagawa (School of Pharmaceutical Sciences, University of Shizuoka)
P08-8 Heparin mobilizes human multipotent mesoangioblasts from the heart during cardiac catheterization
Yoshihiro Hata (Department of Medicine II, Kansai Medical University)



Poster session 9

Genetics/Cardiomyopathy

座長:大野 聖子(国立循環器病研究センター研究所 分子生物学部)
発表者:
P09-1 Identification and arrhythmogenic significance of a novel TMEM168 mutation in Brugada syndrome
Dimitar Zankov (Shiga University of Medical Science)
P09-2 Overlapping Brugada syndrome associated with SCN5A mutations in patients with sick sinus syndrome
Asami Kashiwa (Department of Cardiovascular Medicine, Kyoto University)
P09-3 The Ref/Alt imbalance of the VUS in RNAseq affect the gene expression in cardiomyopathy
Yohei Miyashita (Osaka university Dept. of Cardiovascular Medicine)
P09-4 The validation of association of a rare variant in TKS5 with atrial fibrillation (AF) and examination of its role in AF pathogenesis
Xiaoxi Yang (Bio-informational Pharmacology, Tokyo Medical and Dental University, Japan)
P09-5 Gene Expression Landscape of Heart Failure Mice model caused by Cardiac Specific PRMT1 Deficiency
Weizhe Lu (Ph.D. Program in Human Biology, School of Integrative Global Majors (SIGMA), University of Tsukuba)
P09-6 Establishment of Fabry cardiomyopathy model and its isogenic control from a female patient
Yuki Kuramoto (Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine)
P09-7 Involvement of Attenuation of β-Adrenoreceptors Signaling in Development of Takotsubo Syndrome
Tomoya Nakano (Department of Cardiovascular Medicine, Nara Medical University)
P09-8 Single cell analysis of cardiomyocyte reveals spatial and temporal heterogeneity in heart failure

Masahiro Satoh (Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine)



Poster session 10

Inflammation and Fibrosis

座長:竹石 恭知(福島県立医科大学 循環器内科)
発表者:
P10-1 Maternal high-fat diet promotes the expansion of abdominal aortic aneurysm in adult offspring.
Makoto Saburi (Department of Cardiovascular Medicine Kyoto Prefectural University of Medicine)
P10-2 “Human” epicardial adipose tissue induces “rat” atrial myocardial fibrosis through paracrine effects
Shintaro Kira (Department of Cardiology and Clinical Examination, Oita University)
P10-3 NLRP3 Inflammasome Initiated through CaMKIIδ in Cardiomyocytes is Essential for Cardiac Remodeling
Takeshi Suetomi (Yamaguchi University)
P10-4 Involvement of VGLL3 in TGF-beta-induced epithelial-to-mesenchymal transition
Noritaka Yamaguchi (Department of Molecular Cardiovascular Pharmacology, Graduate School of PharmaceuticalSciences, Chiba University)
P10-5 MAIR-II deficiency prevents excessive inflammation and fibrosis post-myocardial infarction
Saori Yonebayashi (Department of Cardiology, University of Tsukuba)
P10-6 The role of cellular senescence in cardiac fibrosis after myocardial infarction
Masato Shibamoto (Department of Cardiovascular Medicine,Osaka University Graduate School of Medicine)
P10-7 Identification of Cardiovascular Dysfunction in Spondyloarthritis Model Rats
Hiroki Hayashi (Osaka University)
P10-8 Beneficial effects of exercise on cardiac fibrosis in obese mice: the role of leptin.
Maria Pini (IMRB - Inserm U955)



Poster session 11

Ischemic cardiovascular disease

座長:瀧本 英樹(東京大学 循環器内科)
発表者:
P11-1 Prevalence of risk factors for CVD among children and adolescents of Asian Indian origin
PARTHA SARATHI DATTA (Department of Anthropology, Visva-Bharati, Santiniketan, India.)
P11-2 Akt1-mediated muscle growth promotes blood flow recovery by enhancing HO-1 in neighboring cells
Yasuhiro Izumiya (Osaka City University)
P11-3 Iron Metabolism in a Mouse Model of Hind Limb Ischemia
Keisuke Okuno (Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine)
P11-4 AIM Depletion Suppressed Cardiac Rupture without Affecting Hemodynamics after MI in Mice
Shohei Ishikawa (Department of Cardiorenal and Cerebrovascular Medicine, Faculty of Medicine, Kagawa University)
P11-5 MURC/Cavin-4 deficiency improves cardiac ischemia-reperfusion injury
Yumika Tsuji (Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine)
P11-6 Lack of Sirt7 attenuates myocardial ischemia-reperfusion injury by modulating NRF2 activity
Satoshi Araki (Department of Cardiovascular Medicine, Faculty of Life Sciences, Kumamoto University)
P11-7 5-Aminolevulinic Acid Combined with Ferrous Iron Ameliorates Cardiac Ischemia/Reperfusion Injury.
Yu Oimatsu (Kumamoto University)
P11-8 Human iPSC-derived cardiac tissue transplantation to a rat unloaded ischemic heart model
DAISUKE HEIMA (Department of Cardiovascular Surgery, Graduate school of Medicine, Kyoto University, Kyoto, Japan)



Poster session 12

Kidney/Interorgan Communication Network

座長:安斉 俊久(北海道大学 循環器内科)
発表者:
P12-1 The Body-wide Transcriptome Landscape of Disease Models
Kyoji Urayama (The Thomas N. Sato BioMEC-X Laboratories, Advanced Telecommunications Research Institute International (ATR), Kyoto, Japan)
P12-2 Purification of the growing skeletal muscle derived exosomal micro RNA.
Toshifumi Ishida (Kumamoto University)
P12-3 Gut Microbiota Depletion Alters Cardiac Hypertrophy in Mice
Takehiro Kamo (The Institute for Adult Diseases, Asahi Life Foundation)
P12-4 The alterations of gut epithelial barrier function in a mouse model of heart failure
Akiko Saga-Kamo (Department of Cardiovascular Medicine, The University of Tokyo Hospital)
P12-5 Gut microbiome composition and plasma microbial metabolites in patients with heart failure
Tomohiro Hayashi (Kobe University Graduate School of Medicine)
P12-6 Serum FABP4 is removed by the kidney via glomerular filtration and megalin-mediated reabsorption
Tatsuya Iso (Gunma University Graduate School of Medicine)
P12-7 Transferrin receptor 1 is associated with the development of diabetic kidney disease
Seiki Yasumura (Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine)
P12-8 Renal Tissue Hypoxia in the Subacute Phase of Renal Ischemia Reperfusion Injury
Pei Chen Connie Ow (National Cerebral and Cardiovascular Research Institute)



Poster session 13

Metabolic syndrome

座長:的場 聖明(京都府立医科大学循環器内科)
発表者:
P13-1 Natriuretic Peptide Induces Adipose Tissue Browning and Thermogenesis in Diet Induced Obese Mice
Haruka Kimura (The Jikei University School of Medicine Division of Cardiology)
P13-2 Brown adipose tissue dysfunction is involved in the pathologies in failing heart
Yohko Yoshida (Niigata University)
P13-3 Psychological stress accelerates HFD-induced insulin resistance by enhancing NE activity in eWAT
Shinichiro Motoyama (Kyoto Prefectural University of Medicine)
P13-4 Adrenomedullin plays a compensatory role in obesity-related hypertension

Kosai Cho (Department of Primary Care and Emergency Medicine, Kyoto University Graduate School of Medicine)

P13-5

Maternal high-fat diet impairs insulin sensitivity by enhancing NLRP3 inflammasome activation

Naotoshi Wada (Kyoto Prefectural Univ of Med)
P13-6 Loss of periostin ameliorates adipose tissue inflammation and fibrosis in vivo
Takahiro Horie (Department of Cardiovascular Medicine, Kyoto University Hospital)
P13-7 Effects of Tofogliflozin on Cardiac Hypertrophy in Metabolic Model Rats

Tomonari Kimura (Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama, Japan.)

P13-8 Insufficient neonatal ketogenesis triggers the susceptible trait for hepatic steatosis
Yuichiro Arima (Department of Cardiovascular Medicine, Kumamoto University)



Poster session 14

Pulmonary Hypertension

座長:杉村 宏一郎(東北大学 循環器内科)
発表者:
P14-1 SOX17 mutations in Japanese patients with pulmonary arterial hypertension
Takahiro Hiraide (Keio University School of Medicine)
P14-2 Pristane might be useful for creating a novel model of CTD-PAH in mice
Hiroyoshi Mori (National Cerebral and Cardiovascular Center Research Institute)
P14-3 TrkB might have a role for right ventricular homeostasis under chronic hypoxia-induced PH
Makoto Okazawa (National Cerebral and Cardiovascular Center)
P14-4 Hypoxia Causes Epigenetic Changes in SMCs of PAH with BMPR2 Mutation
Kazufumi Nakamura (Okayama University)
P14-5 INHBA is a Novel Gene that Regulates Pulmonary Arterial Hypertension Development

Gusty Rizky Teguh Ryanto (Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine)

P14-6 Role of endothelin-1 in the regulation of ALK-1 in human pulmonary arterial endothelial cells
Ryo Kawamata (Fukushima Medical University)
P14-7 Expressional analysis of Endothelin-2 in Lung under Hypoxic Condition
Donytra Arby Wardhana (Clinical Pharmacy, Kobe Pharmaceutical University)
P14-8 Loss of Fam13a exacerbates the vascular remodeling in pulmonary artery hypertension.

Yuko Kuribayashi (Laboratory of Clinical Pharmaceutical Science, Kobe Pharmaceutical University, Kobe, Japan)



Poster session 15

Vascular biology

座長:山下 潤(京都大学 iPS細胞研究所)
発表者:
P15-1 The role of ORAIP for the coronary artery plaque instability in Familial Hypercholesterolemia
Hidekimi Nomura (Tokyo Women's Medical University)
P15-2 Phenotypic change of perivascular adipose tissue associated with endovascular damage

Yusuke Adachi (Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan)

P15-3 Adipose-ERK2 Protect From Ectopic Fat Depositions and Vascular Dysfunction in Obesity
Ayumu Osaki (National Defense Medical College)
P15-4 The role of redox regulation of PKG1α on sympathetic nervous system in salt sensitive hypertension.

Nobuyuki Tokunaga (Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.)

P15-5

ChGn-2 Deletion Reduces Lipoprotein Retention and PDGF-mediated Aortic Smooth Muscle Cells Migration

Imam Manggalya Adhikara (Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine)

P15-6 Cre expression in hematopoietic cells of smooth muscle cell-targeted Cre recombination mice
Tomohiko Ishibashi (National Cerebral and Cardiovascular Center Research Institute)
P15-7 SREBF1/MicroRNA-33b axis exhibits potent effect on unstable atherosclerotic plaque formation in vivo
Takahiro Horie (Kyoto University)
P15-8 Unanticipated roles of IKKβ in vascular calcification
Noboru Ashida (Kyoto University Graduate School of Medicine, Department of Cardiovascular Medicine)



Poster session 16

Arrhythmia

座長:小林 茂樹(山口大学医学部医学科 器官病態内科学)
発表者:
P16-1 Atrial Fibrillation Detection Using Convolutional Neural Networks
Xue Zhou (University of Aizu)
P16-2 Non-uniform calcium dynamics of the atrial cells and Purkinje fibers with references to T tubules
Hideo Tanaka (Kyoto Prefectural University of Medicine)
P16-3 THREE-DIMENSIONAL STRUCTURAL ANALYSIS OF MUTANT RYR2 CHANNELS ASSOCIATED WITH CPVT
Jingshan Gao (Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine)
P16-4 Glucose fluctuations in diabetic mice induce cardiac sinoatrial node dysfunction.

Takahiro Oniki (Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University)

P16-5 SERCA2 C674S heterozygote knock-in mice with angiotensin infusion leads to ventricular arrhythmia
Kei Ito (National Defense Medical College)
P16-6 Inhibition of HDAC 6 manipulates electrophysiological properties of HL-1 cells
Peili Li (Tottori University)
P16-7 Pacemaker activity generated by CRISPR/Cas9 based genome editing for Kcnj2
Kensuke Ihara (Department of Bio-informational Pharmacology, Tokyo Medical and Dental University)



Poster session 17

Diabetes and CVD

座長:坂東 泰子(名古屋大学)
発表者:
P17-1

Mechanisms for Ca2+signaling defects underlying diastolic dysfunction in diabetic

cardiomyopathy

Yoshinori Mikami (Department of Physiology, Faculty of Medicine, Toho University)
P17-2 Physiological role of TRPC6 upregulation in hyperglycemic rodent hearts

Sayaka Oda (Division of Cardiocirculatory Signaling, National Institute for Physiological Sciences (Exploratory Research Center on Life and Living Systems), National Institutes of Natural Sciences)

P17-3 Activation of SERCA2 ameliorated endothelial function and skeletal muscle function of db/db mice
Toyokazu Kimura (National Defense Medical College)
P17-4 Understanding the pathogenesis of diastolic dysfunction: from the whole heart to the myofilament
Mark T Waddingham (National Cerebral and Cardiovascular Center, Suita, Osaka, Japan)
P17-5 Impact of insulin resistance on right heart failure in sugen chronic hypoxia rats

Huiling Jin (Department of Cardiac Physiology National Cerebral Cardiovascular Center Research Institute)

P17-6 SGLT1 exhibits ischemic tolerance and contributes to cardioprotection in diet-induced obese mice
Akira Yoshii (The Jikei University School of Medicine, Division of Cardiology)
P17-7 Glucagon plays protective role against catecholamine surge in heart failure
Kazuyuki Nishimura (Nagoya University Graduate school of Medicine)



Poster session 18

Mitochondria/Organelles

座長:山口 修(愛媛大学 循環器・呼吸器・腎高血圧内科学)
発表者:
P18-1 Novel compound heterozygous TMEM70 variants impaired the activity of ATP synthase of complex V
Keiichi Hirono (University of Toyama)
P18-2 HERPUD1 protects against ER stress- and oxidative stress-induced cardiomyocyte death

Soichiro Ikeda (Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan)

P18-3 FKBP8 protects the heart by preventing accumulation of misfolded protein and ER-associated apoptosis
Tomofumi Misaka (Fukushima Medical University)
P18-4 Oxidant stress terminates protective signals in mitochondria by recruitment of DUSP5 and PHLPP-1.
Wataru Ohwada (Sapporo Medical University)
P18-5 Inhibition of xanthine oxidase prevents skeletal muscle mitochondrial dysfunction in heart failure

Hideo Nambu (Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University)

P18-6 Cilnidipine improves heart failure after myocardial infarction by suppressing mitochondrial fission

Kakeru Shimoda (Creative Research Group on Cardiocirculatory Dynamism, Exploratory Research Center on Life and Living Systems (ExCELLs), National Institutes of Natural Sciences)

P18-7 Supplementation of succinyl-CoA improves the mitochondrial complex II dysfunction in heart failure
Satoshi Maekawa (Hokkaido University)

Travel Award

海外から参加し発表を行う筆頭著者を対象に審査のうえ、Travel Awardを授与します。